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KMID : 1123920160300010040
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 1 p.40 ~ p.46
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Screening of Positive Inotropic Effect from Herbal Extracts in Beating Rabbit Atria
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Lee Yun-Jung
Kwon Oh-Jeong
Kim Hye-Yoom
Namgung Seung
Lee Jae-Yun
Yu Yun-Cho
Kang Dae-Gill
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Abstract
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Many medicinal plants have been used for the treatment of edema, jaundice, and gonorrhea in traditional Oriental medicine. This screening study was designed to search the positive inotropic effects of herbal extracts in beating rabbit atria. Aquarius extracts of twenty six herbs were examined in atrial mechanical dynamics such as pulse pressure and stroke volume and atrial natriuretic peptide (ANP), one of the main hormones involved in the regulation of the body fluid and blood pressure homeostasis in perfused beating rabbit atria. Sophora flavescens Ait., Rheum officinale Baill., Acorus gramineus Sol., Chelidonium majus L., Pulsatilla koreana Nakai., Reynoutria japonica Houtt., Euphorbia lathyris L., Pyrrosia lingua (Thunb.) Farwell, Poncirus trifoliata Rafin., Anemarrhena asphodeloides Bunge, Kochia scoparia Schrad. significantly increased stroke volume and pulse pressure. However, those herbal extracts were not induced ANP secretion. We clarified the eleven herbal extracts for the positive inotropic effect independent of ANP secretion in beating rabbit atria. Thus these results provide a beneficial data for the treatment of the impairment of body fluid and blood pressure in traditional Oriental medicine.
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KEYWORD
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Positive inotropic effect, Atrial dynamics, ANP, Stroke volume, Pulse pressure
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